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The demand for pharmaceutical-grade peptides explored for metabolic research has grown rapidly in recent years. Three notable examples — Semaglutide, Tirzepatide, and Retatrutide — have each attracted attention for their potential to support studies involving appetite regulation, metabolism, and energy balance.

At EU Pharmaceuticals, we provide high-purity, research-grade peptides designed for controlled laboratory use. The following overview summarizes current publicly available data for educational and comparative reference.

Peptide Overview

Peptide Type Brand / Reference Primary Research Focus
Semaglutide GLP-1 Receptor Agonist Ozempic®, Wegovy® Appetite signalling and gastric motility studies
Tirzepatide Dual GIP + GLP-1 Agonist Mounjaro® Insulin and satiety pathway analysis
Retatrutide Triple Agonist (GLP-1 + GIP + Glucagon) (In clinical evaluation) Thermogenesis and metabolic regulation research

Mechanistic Summary

  • Semaglutide — Mimics GLP-1 activity, influencing appetite and glucose-related pathways.
  • Tirzepatide — Acts on both GLP-1 and GIP receptors, extending the metabolic signalling range.
  • Retatrutide — Adds glucagon receptor activity, studied for its role in energy expenditure.

Comparative Research Data

Peptide Reported Body-Weight Change* Study Duration
Semaglutide ≈ 15% (average across published trials) 60–68 weeks
Tirzepatide ≈ 20–22.5% 72 weeks
Retatrutide ≈ 24.2% (in-trial data) 48–72 weeks

*Data from publicly available human clinical studies. For informational comparison only.

Dosing & Titration (Research Reference)

Peptide Starting Reference Maximum Reference Titration (Study Model)
Semaglutide 0.25 mg / week 2.4 mg / week 4–8 week incremental titration
Tirzepatide 2.5 mg / week 15 mg / week Weekly 2.5 mg increments
Retatrutide 1–2 mg / week (trial) 8–12 mg / week (anticipated) Gradual titration per study design

Observed Tolerability (Published Studies)

Peptide Gastrointestinal Events Hypoglycemia Risk Notes
Semaglutide Moderate Low Long-term safety profile established
Tirzepatide Moderate Slightly higher Some reports of thyroid marker changes
Retatrutide Higher incidence (trial data) Under evaluation Occasional elevated heart-rate observations

Availability at EU Pharmaceuticals

  • Semaglutide: 5 mg vials
  • Tirzepatide: 10 mg vials
  • Retatrutide: 5 mg and 10 mg vials

Research Selection Guide

Objective Representative Compound
Gradual, validated model reference Semaglutide
Faster, dual-pathway investigation Tirzepatide
Next-generation, multi-agonist exploration Retatrutide

Summary

Semaglutide, Tirzepatide, and Retatrutide each represent significant advances in peptide-based metabolic research. Selection depends on experimental objectives, tolerance parameters, and study design. EU Pharmaceuticals provides premium-grade reference materials to support informed, compliant, and reproducible laboratory work.

All information is provided for laboratory, educational, and research reference only. Compounds are not approved for human or veterinary use. Any therapeutic or medical interpretation falls outside the intended scope of this material.